Browsing by Author "Lavandero González, Sergio Alejandro"

Now showing items 1-12 of 12

    • Autophagy in aging-related oral diseases 
      Peña Oyarzún, Daniel; San Martin, Carla; Hernández Cáceres, María Paz; Lavandero González, Sergio Alejandro; Morselli, Eugenia; Budini Budini, Mauricio Fernando; Burgos, Patricia V.; Criollo Céspedes, Alfredo Guillermo (Frontiers Media, 2022)
      Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite availability modulating metabolic pathways, differentiation and cell ...
    • Circulating vascular cell adhesion molecule-1 (sVCAM-1) is associated with left atrial remodeling in ... 
      Contreras Briceño, Felipe Andrés; Herrera, Sebastián; Vega Adauy, Julián; Salinas, Manuel; Ocaranza, María Paz; Jalil, Jorge E.; Mandiola, Jorge; Garcia Nannig, Lorena del Pilar; Chiong Lay, Mario Martin; Castro, Pablo F.; Lavandero González, Sergio Alejandro; Gabrielli, Luigi (Frontiers Media, 2021)
      An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated ...
    • Cooperative binding of ETS2 and NFAT links erk1/2 and calcineurin signaling in the pathogenesis of cardiac ... 
      Luo, Yuxuan; Jiang, Nan; May, Herman I.; Luo, Xiang; Ferdous, Anwerul; Schiattarella, Gabriele G.; Chen, Guihao; Li, Qinfeng; Li, Chao; Rothermel, Beverly A.; Jiang, Dingsheng; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2021)
      Background: Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally. The calcineurin/NFAT (nuclear factor of activated T cells) pathway and the MAPK ...
    • Efecto de exosomas aislados de células endoteliales tratadas con Interleuquina-10 en la expresión de ... 
      Zúñiga Cuevas, Úrsula Almendra (Universidad de Chile, 2022)
      Antecedentes: El envejecimiento y la inflamación crónica de bajo grado son factores de riesgo para el desarrollo de enfermedades cardiovasculares. También se conoce que la inflamación vascular crónica promueve la disfunción ...
    • Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells 
      López Crisosto, Camila Paz; Díaz Vegas, Alexis; Castro, Pablo F.; Rothermel, Beverly A.; Bravo Sagua, Roberto Francisco; Lavandero González, Sergio Alejandro (SpringerNature, 2021)
      Subcellular organelles communicate with each other to regulate function and coordinate responses to changing cellular conditions. The physical-functional coupling of the endoplasmic reticulum (ER) with mitochondria allows ...
    • Estudio de la acción cardioprotectora del retroenantio de angiotensina-(1-9) en isquemia-reperfusión 
      Flores León, Yvo (Universidad de Chile, 2023)
      Angiotensina-(1-9) [Ang-(1-9)] es un nonapéptido derivado del sistema renina-angiotensina no canónico cuyo efecto cardioprotector está mediado a través de su unión al receptor de angiotensina subtipo 2 (AT2R) y su posterior ...
    • Estudio de la regulación de MUL1 por insulina en células musculares 
      López Gallardo, Erik Alexander (Universidad de Chile, 2023)
      Introducción. La insulina regula la dinámica y función mitocondrial mediante la vía de Akt, generando un fenotipo mitocondrial elongado y estimulando el metabolismo oxidativo mitocondrial en células musculares. MUL1, una ...
    • Fenretinida como terapia preventiva de la progresión de la cardiomiopatía inducida por dieta alta en grasa 
      Muñoz Córdova, Felipe Andrés (Universidad de Chile, 2023)
      La fenretinida, un derivado retinoide sintético clínicamente seguro, posee efectos quimioterápicos y quimiopreventivos con mínimos efectos adversos. Estudios preclínicos han mostrado que este fármaco podría tener un segundo ...
    • Perspectives on organelle interaction, protein dysregulation, and cancer disease 
      Díaz, Paula; Sandoval Bórquez, Alejandra María Loreto; Bravo Sagua, Roberto Francisco; Quest, Andrew Frederick Geoffery; Lavandero González, Sergio Alejandro (Frontiers Media, 2021)
      In recent decades, compelling evidence has emerged showing that organelles are not static structures but rather form a highly dynamic cellular network and exchange information through membrane contact sites. Although ...
    • Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells 
      Mondaca Ruff, David Gonzalo; Quiroga, Clara; Norambuena Soto, Ignacio Estebán; Riquelme Meléndez, Jaime Andrés; San Martin, Alejandra; Bustamante Parraguez, Mario Andrés; Lavandero González, Sergio Alejandro; Chiong Lay, Mario Martín (Wiley, 2022)
      Hypertension is associated with high circulating angiotensin II (Ang II). We have reported that autophagy regulates Ang II-induced vascular smooth muscle cell (VSMC) hypertrophy, but the mechanism mediating this effect is ...
    • Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy 
      Troncoso Magñin, Mayarling Francisca; Pavez Giani, Mario Gustavo; Wilson Rodríguez, Carlos Antonio; Lagos Cerón, Daniel Alejandro; Durán Gárate, Javier Andre; Ramos, Sebastián; Barrientos Briones, Genaro Christian; Silva, Patricio; Llanos Vidal, Paola Andrea; Basualto Alarcón, Carla Edith; Westenbrink, B. Daan; Lavandero González, Sergio Alejandro; Estrada Hormazábal, Manuel Iván (BMC, 2021)
      Background Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that ...
    • Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ... 
      Schiattarella, Gabriele G.; Altamirano, Francisco; Young Kim, Soo; Tong, Dan; Ferdous, Anwarul; Piristine, Hande; Dasgupta, Subhajit; Wang, Xuliang; French, Kristin M.; Villalobos, Elisa; Spurgin, Stephen B.; Waldman, Maayan; Jiang, Nan; May, Herman I.; Hill, Theodore M.; Luo, Yuxuan; Yoo, Heesoo; Zaha, Vlad G.; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2021)
      Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular ...